Fiberman, fiberman...
Ah...a subject to chime in on! I'm new to these forums but I've been fighting with fibre for as long as it's been around...or the late 80's at least!
Up here (in VOC friendly Canada) I use a product manufactured by ML Campbell's Canadian subsidiary called "Clawlock", specifically formulated for just this purpose. This is a high-solids, two component (post-catalyzed), Amino Alkyd formulation; I use standard (89C grade) premium lacquer thinner as the reducer in most cases (16-20 secs; #4 Ford Cup) although high-end ferbo reducer provides slightly better performance in some situations (i.e. boxes with the

backs nailed on them). I spray conventional, one pass around the profiles and edges (cut surfaces), thirty minutes on the drying rack then sand til there's virtually nothing left (but there is

). I then shoot a full coat (20-24 secs viscosity) on everything (I hang most everything I can: doors, fillers, end panels) and allow for full cure (8 or so hours) prior to finish sanding. Depending on the quality of the fibre and the gloss level of the top coat, I may give the front faces a second pass to assure the necessary fill during finish sand. Finish is generally two coats ML Campbell "Resistant" high solids post cat, shot wet on wet with a Kremlin MX air-assisted airless; then 24 hour cure prior to packing or installation. For 95 point (i.e. mirrors), the "Resistant" is "watered" way back with ferbo and shot in two, two coat sessions with a cure and wet sand to 600 grit on day 2 and powerbuff when the second two passes have cured.
All that said, obviously this doesn't apply (whatsoever) to conditions "in the field", however this IS how I deal with MDF (in a shop with a booth).
IMO, if you have to deal with lots of fibreboard, high solids catalyzed primers are the only way to go (respirator is not optional :no

and the investment in a pot, pistol and compressor will quickly pay for itself...Even if you are topcoating with more "conventional" products.
Cheers, Ron
PS: To prempt the inevitable "why would you use a pressure pot?"...superior fan control and superior atomization of high solids primers when doing cabinet grade finishes...(we're not shooting blockfiller here)...and besides, the customer also pays for the overspray when they pay for their doors!